One student posted the following query in the discussion forum of our on-line [1] Course Management Software:

Why do we hiccup?

Another student posted a link to the following article, and I thought to myself: "Who is paying for hiccup research? Wouldn't those funds be better spent researching diseases that actually have negative influences on human morbidity and mortality, rather than a phenomenon that is, at worst, a minor annoyance and barely noticed?"

Considering the fact that almost everyone experiences hiccups at one time or another, remarkably little is known about them. The name itself is onomatopoeic, which is appropriate considering that the only common understanding of the hiccup is of the characteristic sound. Hiccups can be predictably elicited in some individuals by overindulgence of food, alcohol, or both, sometimes providing evidence of such behaviour and making them a common object of humour. There are, however, instances in which hiccups become intractable (singultus) causing insomnia, wasting, exhaustion, and even death, prompting scientific scrutiny of this otherwise harmless curiosity. In this issue Fass et al (see page 590) present original investigative work on the afferent limb of the hiccup reflex.

Fass et al used a barostat to characterise the parameters of oesophageal distention that could elicit hiccups in normal volunteers. They report that rapid phasic distension of the proximal, but not distal, oesophagus could reproducibly induce hiccups in four of 10 subjects. Hiccups occurred during rapid inflation of the barostat bag and immediately resolved with deflation, strongly implicating oesophageal mechanoreceptors as the critical afferents. The authors speculatively generalise this observation to the population as a whole, but in this one needs to be circumspect, recognising the long list of stimuli that have been reported to cause prolonged bouts of hiccups. A partial inventory of hiccup aetiologies encompasses trauma (skull fracture, closed head trauma, surgery), mass lesions (aneurysms, tumours, goitres, diverticuli), infections (subdiaphragmatic abscess, cholecystitis, pleurisy, meningitis, encephalitis), irritative stimuli (heartburn, spicy food, gastritis, peptic ulcers, pancreatitis), luminal distension (achalasia, gastric distension, oesophageal rings and strictures), central nervous system pathology (multiple sclerosis, cerebrovascular accidents, psychogenic), and metabolic aberrations (uraemia, drugs). One individual is described in whom a hair tickling the tympanic membrane was ultimately revealed to be the cause of singultus. In view of this great diversity of causative stimuli, defining the afferent limb of the hiccup reflex is no simple task and there is reason to suspect substantial intersubject variability. In the broadest sense, relevant afferents can course with the vagus or phrenic nerves, the pharyngeal plexus from C2 to C4, and the sympathetic chain from T6 to T12. In all likelihood, there is no universal stimulus for hiccups in adults, but rather, a long list of potential stimuli in susceptible individuals.

The central elements and efferent limbs of the hiccup reflex have been better characterised than the afferent limb. The hiccup is an involuntary medullary reflex influenced by, but independent of, the respiratory centre of the medulla. In a meticulous investigation, Davis demonstrated that hiccup frequency could be modulated or completely suppressed by inhalation of CO2 (the physiology behind the remedies of rebreathing into a paper bag and breath holding).6 Furthermore, the whole array of inspiratory muscles are activated on the efferent side of the reflex: the phrenic nerves to the diaphragm, the external intercostal nerves (T1-T11) to the intercostal muscles, and the scalenus anticus nerve to the scalene muscles which elevate the clavicles. These inspiratory efferents are activated far more vigorously during hiccups than during cyclic respiration. Thirty five milliseconds after inspiratory activation, the recurrent laryngeal nerve effects glottic closure, resulting in the characteristic "hic" and eliminating any ventilatory effect of the reflex. The large volume changes which would occur in hiccups were it not for the associated glottal closure is evident in tracheostomised individuals in whom hiccups can cause severe hyperventilation; Davis reports such a case in which hiccups resulted in an arterial pH of 7.58 and a minute ventilation exceeding 20 litres. Thus, although the hiccup reflex results in repetitive, essentially maximal stimulation of the inspiratory musculature, it normally serves no respiratory function.

Source/More at [2] Gut Online (British Medical Journal)